Clearance in First Order and Zero Order Elimination Kinetic

Clearance is an imaginary volume of plasma from which a drug is completely removed in unit time.

↓

elimination process is not saturated

↓

at higher concentrations of drug → more drug molecules are eliminated &

at lower concentrations of drug → less drug molecules are eliminated

↓

the volume of plasma from which drug is completely removed remains constant

↓ i.e. clearance remains constant.

↓

elimination process is saturated

↓

fixed number of drug molecules are eliminated irrespective of plasma concentration of drug

↓ at higher concentrations → less plasma is cleared &

at lower concentrations → more plasma is cleared

↓

i.e. clearance is not constant.

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