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Hofmann Elimination

Hofmann Elimination

• Is the spontaneous inactivation of the drug in the body without the involvement of any enzyme.

Example

• Atracurium

• Cisatracurium

Advantage

Elimination of such drugs is not affected in hepatic and renal insufficiency

↓

can be safely used in such patients.

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Pharmacodynamics > ▶️ Mechanism of Action of Drugs