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Methods to Modify Rate of Drug Absorption



Slow Release Dosage Forms

  • e.g. retard tablets, spansules, depot injections, subcutaneous implants etc.

  • Release drug slowly → prolonged action.

Enteric Coated Tablets

  • Coating prevents the degradation of drug by gastric acid → drug is absorbed from intestine.

  • Acid labile drugs can be given orally in this form.

Changing Physical Characteristics of the Drug

e.g:

Ultralente insulin

↓

Large crystalline particles which are insoluble in water

↓

release insulin slowly

↓

prolonged action

----


Semilente insulin

↓

Smaller amorphous particles

↓

release insulin fast

↓

quick action


Adding Vasoconstrictor or Applying Tourniquet

↓

decrease blood flow

↓

decrease absorption

  • e.g. combining vasoconstrictor with local anesthetic to prolong local action and decrease systemic toxicity of anesthetic.

Adding hyaluronidase to the injection

Hyaluronidase breaks down the matrix

↓

promotes the spread of drug

↓

increased absorption.


Rubbing & Massage

  • Increase absorption.

 

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